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Ler A, Polydoro M, Luebke JI, Spires-Jones TL. The intersection of

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Ler A, Polydoro M, Luebke JI, Spires-Jones TL. The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease. Ageing Res Rev. 2013;12:757?3. doi:10.1016/j.arr.2013.03.002. 12. Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron. 2003;40:471?3. doi:10.1016/S08966273(03)00627-5. 13. Dawkins E, Small DH. Insights into the physiological function of the amyloid precursor protein: Beyond Alzheimer's disease. J Neurochem. 2014; 129:756?9. doi:10.1111/jnc.12675. 14. Delvaux E, Bentley K, Stubbs V, Sabbagh M, Coleman PD. Differential processing of amyloid precursor protein in brain and in peripheral bloodKurbatskaya et al. Acta Neuropathologica Communications (2016) 4:Page 14 of15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30. 31.32.33.leukocytes. Neurobiol Aging. 2013;34:1680?. doi:10.1016/j.neurobiolaging. 2012.12.004. Demuro A, Smith M, Parker I. Single-channel Ca2+ imaging implicates Abeta 1?2 amyloid pores in Alzheimer's disease pathology. J Cell Biol. 2011;195: 515?4. doi:10.1083/jcb.201104133. Dorostkar MM, Burgold S, Filser S, Barghorn S, Schmidt B, Anumala UR, Hillen H, Klein C, Herms Ivacaftor J. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25751659 Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model. Brain. 2014;137: 3319?6. doi:10.1093/brain/awu280. Ferreira A, Bigio EH. Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies. Mol Med. 2011;17: 676?5. doi:10.2119/molmed.2010.00220. Ferreira IL, Ferreiro E, Schmidt J, Cardoso JM, Pereira CMF, Carvalho AL, Oliveira CR, Rego AC. Abeta and NMDAR activation cause mitochondrial dysfunction involving ER calcium release. Neurobiol Aging. 2015;36:680?2. doi:10.1016/j. neurobiolaging.2014.09.006. Garwood C, Faizullabhoy A, Wharton SB, Ince PG, Heath PR, Shaw PJ, Baxter L, Gelsthorpe C, Forster G, Matthews FE, Brayne C, Simpson JE; MRC Cognitive Function and Ageing Neuropathology Study Group. Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol. 2013;39:788?9. doi:10.1111/nan.12033. Giese KP. Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer's disease. Front Mol Neurosci. 2014;7:36. doi:10.3389/fnmol.2014.00036. Gilley J, Orsomando G, Nascimento-Ferreira I, Coleman MP. Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons. Cell Rep. 2015;10:1974?1. doi:10.1016/j.celrep.2015.02.060. Gladding CM, Sepers MD, Xu J, Zhang LYJ, Milnerwood AJ, Lombroso PJ, Raymond LA. Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a huntington's disease mouse model. Hum Mol Genet. 2012;21:3739?2. doi:10.1093/hmg/dds154. G ez-Sintes R, Hern dez F, Bortolozzi A, Artigas F, Avila J, Zaratin P, Gotteland JP, Lucas JJ. Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice. EMBO J. 2007;26: 2743?4. doi:10.1038/sj.emboj.7601725. Go -Oliver P, Lucas JJ, Avila J, Hern dez F. N-terminal cleavage of GSK-3 by calpain: A new form of GSK-3 regulation. J Biol Chem. 2007;282:22406?13. doi:10.1074/jbc.M702793200. Grynspan F, Griffin WR, Cataldo A, Katayama S, Nixon RA. Active sitedirected antibodies identify calpain II as an early- appearing and pervasive component of neurofib.


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