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Tamento de Ciencias Microbiol icas, Laboratorio de Inmunolog , Facultad de Veterinaria, UDELAR, Montevideo, Uruguay. 4Departamento de Farmacoci cias, Universidade Federal de Ci cias da Sa e de Porto Alegre, Rua Sarmento Leite, 245, Porto Alegre 90050-170, RS, Brazil. 5Laborat io de Qu ica e Fun o de Prote as e Pept eos BB ENF and Unidade de Experimenta o Animal, Avenida Alberto Lamego, 2000, Horto, Campos 2-(2-Aminoethoxy)-5-chloropyridine hydrochloride dos Goytacazes 28015-620, RJ, Brazil. 6Faculdade de Veterin ia, Universidade Federal do Rio Grande do Sul, Avenida Bento Gon lves, 9090, Porto Alegre 91540-000, RS, Brazil. 7Instituto Nacional de Ci cia e Tecnologia em Entomologia Molecular, Rio de Janeiro, Brazil.Parizi et al. Parasites Vectors (2015) 8:Page 10 ofReceived: seventeen December 2014 Recognized: 16 FebruaryReferences one. Nicklin MJ, Barrett AJ. Inhibition of cysteine proteinases and dipeptidyl peptidasei by egg-white cystatin. Biochem J. 1984;223(1):245?3. two. Zavasnik-Bergant T. Cystatin protease inhibitors and immune features. Entrance Biosci. 2008;13:4625?7. 3. Hewitson JP, Grainger JR, Maizels RM. Helminth immunoregulation: the part of parasite secreted proteins in modulating host immunity. Mol 2-(two,4-Dichloro-5-fluorophenyl)oxirane Biochem Parasitol. 2009;167(one):1?1. four. Schwarz A, Valdes JJ, Kotsyfakis M. The job of cystatins in tick physiology and blood feeding. Ticks Tick Borne Dis. 2012;three(3):117?seven. 5. Lu S, Soares TS, Vaz IS, Lovato DV, Tanaka AS. Rmcystatin3, a cysteine protease inhibitor from Rhipicephalus microplus hemocytes linked to immune response. Biochimie. 2014;106C:17?3. 6. Renard G, Lara FA, de Cardoso FC, Miguens FC, Dansa-Petretski M, Termignoni C, et al. Expression and immunolocalization of a Boophilus microplus cathepsin L-like enzyme. Insect Mol Biol. 2002;11(four):325?. 7. Yamaji K, Tsuji N, Miyoshi T, Islam MK, Hatta T, Alim MA, et al. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/24083752 A salivary cystatin, HlSC-1, in the ixodid tick Haemaphysalis longicornis perform roles during the blood-feeding procedures. Parasitol Res. 2009;106(1):sixty one?. 8. Karim S, Miller NJ, Valenzuela J, Sauer JR, Mather TN. RNAi-mediated gene silencing to evaluate the position of synaptobrevin and cystatin in tick blood feeding. Biochem Biophys Res Commun. 2005;334(4):1336?2. nine. Kotsyfakis M, Sa-Nunes A, Francischetti IMB, Mather TN, Andersen JF, Ribeiro JMC. Antiinflammatory and immunosuppressive action of sialostatin L, a salivary cystatin from the tick Ixodes scapularis. J Biol Chem. 2006; 281(36):26298?07. 10. Kotsyfakis M, Karim S, Andersen JF, Mather TN, Ribeiro JMC. Selective cysteine protease inhibition contributes to blood-feeding success PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/13485127 in the tick Ixodes scapularis. J Biol Chem. 2007;282(forty):29256?three. 11. Zhou J, Liao M, Ueda M, Gong H, Xuan X, Fujisaki K. Characterization of an intracellular cystatin homolog with the tick Haemaphysalis longicornis. Vet Parasitol. 2009;160(one?):one hundred eighty?. 12. Zhou J, Liao M, Gong H, Xuan X, Fujisaki K. Characterization of Hlcyst-3 like a member of cystatins with the tick Haemaphysalis longicornis. Exp Appl Acarol. 2010;fifty one(4):327?three. 13. Zhou JL, Ueda M, Umemiya R, Battsetseg B, Boldbaatar D, Xuan XA, et al. A secreted cystatin within the tick Haemaphysalis longicornis and its unique expression designs in relation to innate immunity. Insect Biochem Mol Biol. 2006;36(7):527?five. fourteen. Yamaji K, Tsuji N, Miyoshi T, Hatta T, Alim MA, Anisuzzaman, et al. Hlcyst-1 and Hlcyst-2 are likely inhibitors of HlCPL-A during the midgut of your Ixodid tick Haemaphysalis longicornis. J Vet Med Sci. 2010;72(5):599?04. 15. Grunclova L, Horn M, Vancova M, Sojka D, Franta.


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